Hi,
I run all WxSim programs and personally I keep all of them running 24/7 (never shut any of them down) unless I have to reboot the PC for some reason.
Longest it ran until a windows update required reboot was 3.5 months (no issues ever during that time).
There is as mentioned in post above no reason to keep them running, though also no reason to shut them down.
My weather pc runs WxSim, WxSim-Mate, WxsIm-Lite, Auto-LearnWX, CumulusMX, FWI Calc, Nexstorm, StormStation5, StormvueNGX, and many other programs, including OpenGrads for GFS image creation (which lately is playing up. But all run in what I call Black screen mode (monitor shut down) and only about once a week or more I move the mouse to activate the screen for whatever reason.
regards,